Learning Objectives: As a result of viewing this presentation, participants will be able to: explain the role of growth hormone (GH) and insulin like growth factor-1 (IGF-I) in human growth; recognize the conditions resulting in deficiencies of GH and IGF-I; measure the limitations of GH deficiency and IGF-I deficiency diagnosis and the uncertainties of growth promotion in non-GH and Non-IGF-I deficient states; and appropriately refer for endo-cosmetology.